Name: Succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate, SMCC

Synonym: 4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester

Description about SMCC:

SMCC, also called Succinimidyl cyclohexane Maleimide, is one of  Nanocs' amine and sulfhydryl reactive crosslinkers. This crossliner is non-cleavable and membrane permeable. It contains an amine reactive NHS ester and a sulfhydryl reactive maleimide group. Compared to other maleimide NHS ester, SMCC has higher stability in aqueous solution because of its cyclohexane bridge. NHS esters react with primary amines at pH 7-9 while the maleimide group reacts with available thiol or sulfhydryl at pH 6.5~7.5 to form stable thioether bonds.

Physical Properties of SMCC:

• Appearance: Off-white/white solid;
• Molecular formula: C16H18N2O6;
• Molecular weight: 334.32;
• Spacer arm length: 8.3 angstrom, 9 atoms
• CAS number: 64987-85-5;
• Purity: >95%
• Soluble in DMF or DMSO;

Storage Conditions of SMCC:

• SMCC should be stored at -20 ⁰C or lower. Desiccate. Avoid frequent thaw and freeze.